The contest will mark the 20th meeting between the two programs and the 11th game played in Austin. The Longhorns are 14-5 in the all-time series against the Cyclones and 8-2 at home, including wins in four of the last five games.
Last season, Texas fell to Iowa State 30-7 in Ames as the Cyclones scored 27 points in the second half to overcome a 7-3 halftime deficit.
This season, Iowa State is 3-3 after losing its first three games in Big 12 play to Baylor, Kansas, and Kansas State. Texas is 4-2 after the 49-0 win over Oklahoma in the Cotton Bowl on Saturday, the most points the Longhorns have scored in the rivalry game and the first shutout of the Sooners since 1965.